{"aliases":[{"type":"USBrandName","name":"Proventil"},{"type":"USBrandName","name":"Ventolin"},{"type":"CASRegistryName","name":"51022-70-9"},{"type":"Synonym","name":"salbutamol sulphate"}],"definition":{"html":"The sulfate salt of the short-acting sympathomimetic agent albuterol, a 1:1 racemic mixture of (R)-albuterol and (S)-albuterol with bronchodilator activity. Albuterol stimulates beta2-adrenergic receptors in the lungs, thereby activating the enzyme adenylate cyclase that catalyzes the conversion of ATP to cyclic-3',5'-adenosine monophosphate (cAMP). Increased cAMP concentrations relax bronchial smooth muscle, relieve bronchospasms, and reduce inflammatory cell mediator release, especially from mast cells. To a lesser extent albuterol stimulates beta1-adrenergic receptors, thereby increasing the force and rate of myocardial contraction.","text":"The sulfate salt of the short-acting sympathomimetic agent albuterol, a 1:1 racemic mixture of (R)-albuterol and (S)-albuterol with bronchodilator activity. Albuterol stimulates beta2-adrenergic receptors in the lungs, thereby activating the enzyme adenylate cyclase that catalyzes the conversion of ATP to cyclic-3',5'-adenosine monophosphate (cAMP). Increased cAMP concentrations relax bronchial smooth muscle, relieve bronchospasms, and reduce inflammatory cell mediator release, especially from mast cells. To a lesser extent albuterol stimulates beta1-adrenergic receptors, thereby increasing the force and rate of myocardial contraction."},"drugInfoSummaryLink":null,"nciConceptId":"C47957","nciConceptName":"Albuterol Sulfate","termId":41339,"name":"albuterol sulfate","firstLetter":"a","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"albuterol-sulfate"}