{"aliases":[{"type":"CASRegistryName","name":"1051375-10-0"},{"type":"USBrandName","name":"Apretude"}],"definition":{"html":"A human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI), that is used for pre-exposure prophylaxis (PrEP) to reduce the risk of sexually acquired HIV-1 infection. Upon gluteal intramuscular administration, cabotegravir binds to the active site of HIV integrase and inhibits the activity of HIV integrase, an HIV-1 coded enzyme that is necessary for viral replication. Inhibition of integrase prevents the integration of HIV-1 DNA into host genomic DNA.","text":"A human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI), that is used for pre-exposure prophylaxis (PrEP) to reduce the risk of sexually acquired HIV-1 infection. Upon gluteal intramuscular administration, cabotegravir binds to the active site of HIV integrase and inhibits the activity of HIV integrase, an HIV-1 coded enzyme that is necessary for viral replication. Inhibition of integrase prevents the integration of HIV-1 DNA into host genomic DNA."},"drugInfoSummaryLink":null,"nciConceptId":"C169820","nciConceptName":"Cabotegravir","termId":811240,"name":"cabotegravir","firstLetter":"c","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"cabotegravir"}