{"aliases":[{"type":"USBrandName","name":"Libtayo"},{"type":"CodeName","name":"REGN2810"},{"type":"ChemicalStructureName","name":"immunoglobulin G4, anti-(human programmed cell death protein 1) (human monoclonal REGN2810 heavy chain), disulfide with human monoclonal REGN2810 kappa-chain, dimer"},{"type":"CASRegistryName","name":"1801342-60-8"},{"type":"Synonym","name":"cemiplimab RWLC"},{"type":"Synonym","name":"cemiplimab"}],"definition":{"html":"A human monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed cell death 1 (PD-1, PCD-1) protein, with potential immune checkpoint inhibitory and antineoplastic activity. Upon administration, cemiplimab-rwlc binds to PD-1, inhibits its binding to the PD-1 ligand programmed cell death-1 ligand 1 (PD-L1), and prevents the activation of its downstream signaling pathways. This may restore immune function through the activation of cytotoxic T cells. PD-1, a transmembrane protein in the immunoglobulin superfamily expressed on activated T cells, negatively regulates T-cell activation and effector function when activated by its ligand; it plays an important role in tumor evasion from host immunity.","text":"A human monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed cell death 1 (PD-1, PCD-1) protein, with potential immune checkpoint inhibitory and antineoplastic activity. Upon administration, cemiplimab-rwlc binds to PD-1, inhibits its binding to the PD-1 ligand programmed cell death-1 ligand 1 (PD-L1), and prevents the activation of its downstream signaling pathways. This may restore immune function through the activation of cytotoxic T cells. PD-1, a transmembrane protein in the immunoglobulin superfamily expressed on activated T cells, negatively regulates T-cell activation and effector function when activated by its ligand; it plays an important role in tumor evasion from host immunity."},"drugInfoSummaryLink":{"uri":"https://www.cancer.gov/about-cancer/treatment/drugs/cemiplimab-rwlc","text":"Cemiplimab-rwlc"},"nciConceptId":"C121540","nciConceptName":"Cemiplimab","termId":770083,"name":"cemiplimab-rwlc","firstLetter":"c","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"cemiplimab"}