{"aliases":[{"type":"CASRegistryName","name":"113665-84-2"}],"definition":{"html":"A thienopyridine, with antiplatelet activity. Clopidogrel targets, irreversibly binds to and alters the platelet receptor for adenosine diphosphate (ADP), thereby blocking the binding of ADP to its receptor, inhibiting ADP-mediated activation of the glycoprotein complex GPIIb/IIIa, and inhibiting fibrinogen binding to platelets and platelet adhesion and aggregation. This results in increased bleeding time.","text":"A thienopyridine, with antiplatelet activity. Clopidogrel targets, irreversibly binds to and alters the platelet receptor for adenosine diphosphate (ADP), thereby blocking the binding of ADP to its receptor, inhibiting ADP-mediated activation of the glycoprotein complex GPIIb/IIIa, and inhibiting fibrinogen binding to platelets and platelet adhesion and aggregation. This results in increased bleeding time."},"drugInfoSummaryLink":null,"nciConceptId":"C61686","nciConceptName":"Clopidogrel","termId":818423,"name":"clopidogrel","firstLetter":"c","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"clopidogrel"}