{"aliases":[{"type":"USBrandName","name":"Enacard"},{"type":"ForeignBrandName","name":"Renitec"},{"type":"USBrandName","name":"Vasotec"}],"definition":{"html":"The maleate salt form of enalapril, a dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, enalapril is converted by de-esterification into its active form enalaprilat. Enalaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Enalapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.","text":"The maleate salt form of enalapril, a dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, enalapril is converted by de-esterification into its active form enalaprilat. Enalaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Enalapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow."},"drugInfoSummaryLink":null,"nciConceptId":"C468","nciConceptName":"Enalapril Maleate","termId":42544,"name":"enalapril maleate","firstLetter":"e","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"enalapril-maleate"}