{"aliases":[{"type":"USBrandName","name":"Imbruvica"},{"type":"Synonym","name":"Bruton's tyrosine kinase inhibitor PCI-32765"},{"type":"Synonym","name":"BTK inhibitor PCI-32765"},{"type":"CodeName","name":"CRA-032765"},{"type":"ChemicalStructureName","name":"2-propen-1-one, 1-((3R)-3-(4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo(3,4-d)pyrimidin-1-yl)-1-piperidinyl)-"},{"type":"CASRegistryName","name":"936563-96-1"},{"type":"CodeName","name":"PCI-32765"}],"definition":{"html":"An orally bioavailable, small-molecule inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. Upon oral administration, ibrutinib binds to and irreversibly inhibits BTK activity, thereby preventing both B-cell activation and B-cell-mediated signaling. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is required for B cell receptor signaling, plays a key role in B-cell maturation, and is overexpressed in a number of B-cell malignancies. The expression of BTK in tumor cells is also associated with increased proliferation and survival.","text":"An orally bioavailable, small-molecule inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. Upon oral administration, ibrutinib binds to and irreversibly inhibits BTK activity, thereby preventing both B-cell activation and B-cell-mediated signaling. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is required for B cell receptor signaling, plays a key role in B-cell maturation, and is overexpressed in a number of B-cell malignancies. The expression of BTK in tumor cells is also associated with increased proliferation and survival."},"drugInfoSummaryLink":{"uri":"https://www.cancer.gov/about-cancer/treatment/drugs/ibrutinib","text":"Ibrutinib"},"nciConceptId":"C81934","nciConceptName":"Ibrutinib","termId":638648,"name":"Ibrutinib","firstLetter":"i","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"ibrutinib"}