{"aliases":[{"type":"USBrandName","name":"Humalog"},{"type":"CASRegistryName","name":"133107-64-9"}],"definition":{"html":"A recombinant therapeutic agent which is chemically identical to or similar to endogenous human insulin.  In lispro insulin, the amino acid proline at B-28 and the amino acid lysine at B-29 are reversed, resulting in the rapid dissolution of this insulin to a monomer that is absorbed rapidly after subcutaneous administration.  Lispro insulin is equipotent to human insulin on a molar basis but its effects are faster and of shorter duration.  Endogenous insulin, a pancreatic hormone composed of two polypeptide chains, is important in the normal metabolism of carbohydrates, proteins and fats, promoting glucose utilization and protein synthesis; it has anabolic effects on many types of tissues.","text":"A recombinant therapeutic agent which is chemically identical to or similar to endogenous human insulin.  In lispro insulin, the amino acid proline at B-28 and the amino acid lysine at B-29 are reversed, resulting in the rapid dissolution of this insulin to a monomer that is absorbed rapidly after subcutaneous administration.  Lispro insulin is equipotent to human insulin on a molar basis but its effects are faster and of shorter duration.  Endogenous insulin, a pancreatic hormone composed of two polypeptide chains, is important in the normal metabolism of carbohydrates, proteins and fats, promoting glucose utilization and protein synthesis; it has anabolic effects on many types of tissues."},"drugInfoSummaryLink":null,"nciConceptId":null,"nciConceptName":null,"termId":752177,"name":"insulin lispro","firstLetter":"i","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"insulin-lispro"}