{"aliases":[{"type":"Synonym","name":"penpulimab"},{"type":"CodeName","name":"AK 105"},{"type":"CodeName","name":"AK-105"},{"type":"CodeName","name":"AK105"},{"type":"Synonym","name":"anti-PD-1 monoclonal antibody AK105"},{"type":"CASRegistryName","name":"2350298-92-7"}],"definition":{"html":"A monoclonal antibody directed against the negative immunoregulatory human cell receptor programmed cell death protein 1 (PD-1; PDCD1; CD279), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, penpulimab targets, binds to and inhibits PD-1 and its downstream signaling pathways. This may restore immune function through the activation of T cells and T-cell-mediated immune responses against tumor cells. PD-1, a transmembrane protein in the immunoglobulin superfamily (IgSF) expressed on T cells, functions as an immune checkpoint that negatively regulates T-cell activation and effector function when activated by its ligands programmed cell death-1 ligand 1 (PD-L1) or 2 (PD-L2); it plays an important role in tumor evasion from host immunity.","text":"A monoclonal antibody directed against the negative immunoregulatory human cell receptor programmed cell death protein 1 (PD-1; PDCD1; CD279), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, penpulimab targets, binds to and inhibits PD-1 and its downstream signaling pathways. This may restore immune function through the activation of T cells and T-cell-mediated immune responses against tumor cells. PD-1, a transmembrane protein in the immunoglobulin superfamily (IgSF) expressed on T cells, functions as an immune checkpoint that negatively regulates T-cell activation and effector function when activated by its ligands programmed cell death-1 ligand 1 (PD-L1) or 2 (PD-L2); it plays an important role in tumor evasion from host immunity."},"drugInfoSummaryLink":{"uri":"https://www.cancer.gov/about-cancer/treatment/drugs/penpulimab-kcqx","text":"Penpulimab-kcqx"},"nciConceptId":"C155879","nciConceptName":"Penpulimab","termId":794779,"name":"penpulimab-kcqx","firstLetter":"p","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"penpulimab"}