{"aliases":[{"type":"USBrandName","name":"Perjeta"},{"type":"Synonym","name":"rhuMAb-2C4"},{"type":"LexicalVariant","name":"rhuMAb 2C4"},{"type":"Synonym","name":"2C4 antibody"},{"type":"Synonym","name":"monoclonal antibody 2C4"},{"type":"Abbreviation","name":"MOAB 2C4"},{"type":"Synonym","name":"rhuMAb2C4"},{"type":"Synonym","name":"2C4"},{"type":"CodeName","name":"RO4368451"},{"type":"Synonym","name":"pertuzumab biosimilar HS627"},{"type":"Synonym","name":"pertuzumab biosimilar HLX11"},{"type":"Synonym","name":"pertuzumab biosimilar EG1206A"},{"type":"Synonym","name":"pertuzumab biosimilar TQB2440"},{"type":"CodeName","name":"TQB2440"},{"type":"CodeName","name":"TQB 2440"},{"type":"CodeName","name":"TQB-2440"},{"type":"CodeName","name":"TQB2440"},{"type":"CASRegistryName","name":"380610-27-5"},{"type":"CodeName","name":"EG1206A"},{"type":"CodeName","name":"HLX11"},{"type":"CodeName","name":"HS627"},{"type":"ChemicalStructureName","name":"immunoglobulin G1, anti-(human V (receptor)) (human-mouse monoclonal 2C4 heavy chain), disulfide with human-mouse monoclonal 2C4 kappa-chain, dimer"},{"type":"Synonym","name":"omnitarg"},{"type":"Synonym","name":"pertuzumab biosimilar BCD-178"},{"type":"CodeName","name":"BCD-178"}],"definition":{"html":"A humanized recombinant monoclonal antibody directed against the extracellular dimerization domain of the HER-2 tyrosine kinase receptor. Binding of the antibody to the dimerization domain of the HER-2 tyrosine kinase receptor protein directly inhibits the ability of the HER-2 tyrosine kinase receptor protein (the most common pairing partner) to dimerize with other HER tyrosine kinase receptor proteins; inhibiting receptor protein dimerization prevents the activation of HER signaling pathways, resulting in tumor cell apoptosis.","text":"A humanized recombinant monoclonal antibody directed against the extracellular dimerization domain of the HER-2 tyrosine kinase receptor. Binding of the antibody to the dimerization domain of the HER-2 tyrosine kinase receptor protein directly inhibits the ability of the HER-2 tyrosine kinase receptor protein (the most common pairing partner) to dimerize with other HER tyrosine kinase receptor proteins; inhibiting receptor protein dimerization prevents the activation of HER signaling pathways, resulting in tumor cell apoptosis."},"drugInfoSummaryLink":{"uri":"https://www.cancer.gov/about-cancer/treatment/drugs/pertuzumab","text":"Pertuzumab"},"nciConceptId":"C38692","nciConceptName":"Pertuzumab","termId":322808,"name":"pertuzumab","firstLetter":"p","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"pertuzumab"}