{"aliases":[{"type":"Synonym","name":"3-Isobutyl GABA"},{"type":"CodeName","name":"PD-144723"},{"type":"CodeName","name":"CI-1008"},{"type":"ChemicalStructureName","name":"3-(aminomethyl)-5-methyl-hexanoic acid"},{"type":"USBrandName","name":"Lyrica"},{"type":"CASRegistryName","name":"148553-50-8"},{"type":"CodeName","name":"CI 1008"},{"type":"CodeName","name":"PD 144723"}],"definition":{"html":"A 3-isobutyl derivative of gamma-amino butyric acid (GABA) with anti-convulsant, anti-epileptic, anxiolytic, and analgesic activities. Although the exact mechanism of action is unknown, pregabalin selectively binds to alpha2delta (A2D) subunits of presynaptic voltage-dependent calcium channels (VDCCs) located in the central nervous system (CNS). Binding of pregabalin to VDCC A2D subunits prevents calcium influx and the subsequent calcium-dependent release of various neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, and substance P, from the presynaptic nerve terminals of hyperexcited neurons; synaptic transmission is inhibited and neuronal excitability is diminished. Pregabalin does not bind directly to GABA-A or GABA-B receptors and does not alter GABA uptake or degradation.","text":"A 3-isobutyl derivative of gamma-amino butyric acid (GABA) with anti-convulsant, anti-epileptic, anxiolytic, and analgesic activities. Although the exact mechanism of action is unknown, pregabalin selectively binds to alpha2delta (A2D) subunits of presynaptic voltage-dependent calcium channels (VDCCs) located in the central nervous system (CNS). Binding of pregabalin to VDCC A2D subunits prevents calcium influx and the subsequent calcium-dependent release of various neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, and substance P, from the presynaptic nerve terminals of hyperexcited neurons; synaptic transmission is inhibited and neuronal excitability is diminished. Pregabalin does not bind directly to GABA-A or GABA-B receptors and does not alter GABA uptake or degradation."},"drugInfoSummaryLink":null,"nciConceptId":"C64625","nciConceptName":"Pregabalin","termId":518288,"name":"pregabalin","firstLetter":"p","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"pregabalin"}