{"aliases":[{"type":"CASRegistryName","name":"147098-20-2"},{"type":"USBrandName","name":"Crestor"}],"definition":{"html":"The calcium salt form of rosuvastatin, a statin with antilipidemic activity. Rosuvastatin selectively and competitively binds to and inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a precursor of cholesterol. This leads to a decrease in hepatic cholesterol levels and increase in uptake of LDL cholesterol.","text":"The calcium salt form of rosuvastatin, a statin with antilipidemic activity. Rosuvastatin selectively and competitively binds to and inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a precursor of cholesterol. This leads to a decrease in hepatic cholesterol levels and increase in uptake of LDL cholesterol."},"drugInfoSummaryLink":null,"nciConceptId":"C61933","nciConceptName":"Rosuvastatin Calcium","termId":654583,"name":"rosuvastatin calcium","firstLetter":"r","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"rosuvastatin-calcium"}