{"aliases":[{"type":"USBrandName","name":"Jakafi"},{"type":"Synonym","name":"INCB-18424 phosphate"},{"type":"ChemicalStructureName","name":"(3R)-3-cyclopentyl-3-(4-(7h-pyrrolo(2,3-d)pyrimidin-4-yl)pyrazol-1-yl)propanenitrile phosphate (1:1)"},{"type":"ChemicalStructureName","name":"1H-pyrazole-1-propanenitrile, beta-cyclopentyl-4-(7H-pyrrolo(2,3-d)pyrimidin-4-yl)-,(betaR)-, phosphate (1:1)"},{"type":"CASRegistryName","name":"1092939-17-7"},{"type":"ForeignBrandName","name":"Jakavi"}],"definition":{"html":"The phosphate salt form of ruxolitinib, an orally bioavailable Janus-associated kinase (JAK) inhibitor with potential antineoplastic and immunomodulating activities. Ruxolitinib specifically binds to and inhibits protein tyrosine kinases JAK 1 and 2, which may lead to a reduction in inflammation and an inhibition of cellular proliferation. The JAK-STAT (signal transducer and activator of transcription) pathway plays a key role in the signaling of many cytokines and growth factors and is involved in cellular proliferation, growth, hematopoiesis, and the immune response; JAK kinases may be upregulated in inflammatory diseases, myeloproliferative disorders, and various malignancies.","text":"The phosphate salt form of ruxolitinib, an orally bioavailable Janus-associated kinase (JAK) inhibitor with potential antineoplastic and immunomodulating activities. Ruxolitinib specifically binds to and inhibits protein tyrosine kinases JAK 1 and 2, which may lead to a reduction in inflammation and an inhibition of cellular proliferation. The JAK-STAT (signal transducer and activator of transcription) pathway plays a key role in the signaling of many cytokines and growth factors and is involved in cellular proliferation, growth, hematopoiesis, and the immune response; JAK kinases may be upregulated in inflammatory diseases, myeloproliferative disorders, and various malignancies."},"drugInfoSummaryLink":{"uri":"https://www.cancer.gov/about-cancer/treatment/drugs/ruxolitinibphosphate","text":"Ruxolitinib Phosphate"},"nciConceptId":"C97937","nciConceptName":"Ruxolitinib Phosphate","termId":593437,"name":"ruxolitinib phosphate","firstLetter":"r","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"ruxolitinib-phosphate"}