{"meta":{"totalResults":1,"from":0},"results":[{"aliases":[{"type":"CodeName","name":"ABBV-706"},{"type":"CodeName","name":"ABBV706"},{"type":"CodeName","name":"ABBV 706"},{"type":"Synonym","name":"anti-SEZ6 ADC ABBV-706"}],"definition":{"html":"An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against seizure protein 6 homolog (SEZ6) linked to an undisclosed cytotoxic agent, with potential antineoplastic activity. Upon intravenous administration of anti-SEZ6 ADC ABBV-706, the monoclonal antibody moiety targets and binds to SEZ6 expressed on tumor cells. Upon binding and internalization, the cytotoxic agent is released and kills SEZ6-expressing tumor cells through an as of yet undisclosed mechanism. SEZ6, overexpressed in certain cancers while minimally expressed in normal tissues, may play a role in cell-cell recognition and in neuronal membrane signaling.","text":"An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against seizure protein 6 homolog (SEZ6) linked to an undisclosed cytotoxic agent, with potential antineoplastic activity. Upon intravenous administration of anti-SEZ6 ADC ABBV-706, the monoclonal antibody moiety targets and binds to SEZ6 expressed on tumor cells. Upon binding and internalization, the cytotoxic agent is released and kills SEZ6-expressing tumor cells through an as of yet undisclosed mechanism. SEZ6, overexpressed in certain cancers while minimally expressed in normal tissues, may play a role in cell-cell recognition and in neuronal membrane signaling."},"drugInfoSummaryLink":null,"nciConceptId":"C198215","nciConceptName":"Anti-SEZ6 Antibody-drug Conjugate ABBV-706","termId":811935,"name":"anti-SEZ6 antibody-drug conjugate ABBV-706","firstLetter":"a","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"anti-sez6-antibody-drug-conjugate-abbv-706"}],"links":null}