{"meta":{"totalResults":1,"from":0},"results":[{"aliases":[{"type":"CodeName","name":"AZD8205"},{"type":"Synonym","name":"ADC AZD8205"},{"type":"CodeName","name":"AZD-8205"},{"type":"CodeName","name":"AZD 8205"},{"type":"Synonym","name":"anti-B7-H4/TOP1i ADC AZD8205"},{"type":"Synonym","name":"anti-B7-H4/topoisomerase I inhibitor ADC AZD8205"},{"type":"Synonym","name":"antibody-drug conjugate AZD8205"},{"type":"Synonym","name":"B7-H4 TOP1i ADC AZD8205"}],"definition":{"html":"An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against B7-H4 (V-set domain-containing T-cell activation inhibitor 1; VTCN1; B7x; B7S1) linked to a topoisomerase-1 inhibitor (TOP1i; TOP-Ii), with potential antineoplastic activity. Upon administration, the anti-B7-H4 monoclonal antibody moiety of ADC AZD8205 targets and binds to B7-H4 expressed on tumor cells. Upon binding and internalization, the TOP1i moiety is released, binds to TOP1 and stabilizes cleaved DNA-TOP1 complexes. This prevents DNA re-ligation, induces irreversible DNA strand breaks, prevents DNA repair, and leads to cycle arrest and apoptosis specifically in tumor cells expressing B7-H4. B7-H4, a member of the B7 family of immune modulators, is upregulated in a variety of tumor cell types and tumor-associated macrophages. It negatively regulates T-cell immune responses.","text":"An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against B7-H4 (V-set domain-containing T-cell activation inhibitor 1; VTCN1; B7x; B7S1) linked to a topoisomerase-1 inhibitor (TOP1i; TOP-Ii), with potential antineoplastic activity. Upon administration, the anti-B7-H4 monoclonal antibody moiety of ADC AZD8205 targets and binds to B7-H4 expressed on tumor cells. Upon binding and internalization, the TOP1i moiety is released, binds to TOP1 and stabilizes cleaved DNA-TOP1 complexes. This prevents DNA re-ligation, induces irreversible DNA strand breaks, prevents DNA repair, and leads to cycle arrest and apoptosis specifically in tumor cells expressing B7-H4. B7-H4, a member of the B7 family of immune modulators, is upregulated in a variety of tumor cell types and tumor-associated macrophages. It negatively regulates T-cell immune responses."},"drugInfoSummaryLink":null,"nciConceptId":"C185401","nciConceptName":"Anti-B7-H4/ TOP1i Antibody-drug Conjugate AZD8205","termId":808221,"name":"Anti-B7-H4/ TOP1i Antibody-drug Conjugate AZD8205","firstLetter":"a","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"anti-b7-h4--top1i-antibody-drug-conjugate-azd8205"}],"links":null}