{"meta":{"totalResults":1,"from":0},"results":[{"aliases":[{"type":"Synonym","name":"anti-CD40 agonistic monoclonal antibody CDX-1140"},{"type":"CodeName","name":"CDX 1140"},{"type":"CodeName","name":"CDX-1140"},{"type":"Synonym","name":"agonist CD40 antibody CDX-1140"}],"definition":{"html":"A fully human immunoglobulin G2 (IgG2) agonistic monoclonal antibody targeting the B-cell surface antigen CD40, with potential immunostimulatory and antineoplastic activities. Upon administration, CDX-1140 targets and binds to CD40 on a variety of immune cell types. This induces CD40-dependent signaling pathways, triggers the proliferation and activation of antigen-presenting cells (APCs) and activates T cells. This results in an enhanced cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. CD40, a cell surface receptor and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on various immune cells, such as dendritic cells (DCs), macrophages and B cells, and plays a key role in the activation of the immune system.","text":"A fully human immunoglobulin G2 (IgG2) agonistic monoclonal antibody targeting the B-cell surface antigen CD40, with potential immunostimulatory and antineoplastic activities. Upon administration, CDX-1140 targets and binds to CD40 on a variety of immune cell types. This induces CD40-dependent signaling pathways, triggers the proliferation and activation of antigen-presenting cells (APCs) and activates T cells. This results in an enhanced cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. CD40, a cell surface receptor and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on various immune cells, such as dendritic cells (DCs), macrophages and B cells, and plays a key role in the activation of the immune system."},"drugInfoSummaryLink":null,"nciConceptId":"C150558","nciConceptName":"Anti-CD40 Agonist Monoclonal Antibody CDX-1140","termId":793440,"name":"anti-CD40 agonist monoclonal antibody CDX-1140","firstLetter":"a","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"anti-cd40-agonist-monoclonal-antibody-cdx-1140"}],"links":null}