{"meta":{"totalResults":1,"from":0},"results":[{"aliases":[{"type":"Synonym","name":"endothelin B receptor blocker ENB 003"},{"type":"CASRegistryName","name":"2364572-10-9"},{"type":"Synonym","name":"ETBR blocker ENB 003"},{"type":"CodeName","name":"ENB 003"},{"type":"CodeName","name":"ENB003"},{"type":"CodeName","name":"ENB-003"}],"definition":{"html":"An antagonist of the immune checkpoint endothelin B receptor (ETBR; EDNRB), with potential immunomodulating and antineoplastic activities. Upon administration, the ETBR blocker ENB 003 selectively targets and binds to ETBR expressed on tumor cells. This prevents ETBR-mediated signaling and may abrogate the immunosuppressive tumor microenvironment (TME), may enhance a T-cell mediated anti-tumor immune response and may inhibit proliferation of ETBR-expressing tumor cells. ETBR, a G-protein coupled receptor, is overexpressed in a variety of tumor cell types and plays a key role in tumor cell proliferation, invasion, epithelial-mesenchymal transition (EMT) and angiogenesis. It also plays a role in tumor immunosuppression and blocks T-cell trafficking.","text":"An antagonist of the immune checkpoint endothelin B receptor (ETBR; EDNRB), with potential immunomodulating and antineoplastic activities. Upon administration, the ETBR blocker ENB 003 selectively targets and binds to ETBR expressed on tumor cells. This prevents ETBR-mediated signaling and may abrogate the immunosuppressive tumor microenvironment (TME), may enhance a T-cell mediated anti-tumor immune response and may inhibit proliferation of ETBR-expressing tumor cells. ETBR, a G-protein coupled receptor, is overexpressed in a variety of tumor cell types and plays a key role in tumor cell proliferation, invasion, epithelial-mesenchymal transition (EMT) and angiogenesis. It also plays a role in tumor immunosuppression and blocks T-cell trafficking."},"drugInfoSummaryLink":null,"nciConceptId":"C175447","nciConceptName":"Vodudeutentan Sodium","termId":802784,"name":"Vodudeutentan Sodium","firstLetter":"v","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"vodudeutentan-sodium"}],"links":null}