{"meta":{"totalResults":1,"from":0},"results":[{"aliases":[{"type":"CodeName","name":"GS-1811"},{"type":"CodeName","name":"JTX-1811"},{"type":"Synonym","name":"anti-C-C-chemokine receptor 8 monoclonal antibody GS-1811"},{"type":"CodeName","name":"GS 1811"},{"type":"CodeName","name":"GS1811"},{"type":"CodeName","name":"JTX 1811"},{"type":"CodeName","name":"JTX1811"}],"definition":{"html":"A humanized immunoglobulin G1 (IgG1) afucosylated monoclonal antibody against C-C-chemokine receptor 8 (CCR8), with potential immunomodulating and antineoplastic activities. Upon administration, anti-CCR8 monoclonal antibody GS-1811 targets and binds to CCR8 on CCR8-positive, immunosuppressive tumor-infiltrating T-regulatory (TITR) cells in the tumor microenvironment (TME), and prevents chemokine ligand 1 (CCL1)-CCR8-mediated signaling. GS-1811 depletes CCR8-positive TITR cells via antibody-dependent cell-mediated cytotoxicity (ADCC), which may reactivate antitumor immune responses. CCR8 is specifically expressed by TITR cells in multiple types of cancer and plays a key role in immunosuppression.","text":"A humanized immunoglobulin G1 (IgG1) afucosylated monoclonal antibody against C-C-chemokine receptor 8 (CCR8), with potential immunomodulating and antineoplastic activities. Upon administration, anti-CCR8 monoclonal antibody GS-1811 targets and binds to CCR8 on CCR8-positive, immunosuppressive tumor-infiltrating T-regulatory (TITR) cells in the tumor microenvironment (TME), and prevents chemokine ligand 1 (CCL1)-CCR8-mediated signaling. GS-1811 depletes CCR8-positive TITR cells via antibody-dependent cell-mediated cytotoxicity (ADCC), which may reactivate antitumor immune responses. CCR8 is specifically expressed by TITR cells in multiple types of cancer and plays a key role in immunosuppression."},"drugInfoSummaryLink":null,"nciConceptId":"C183159","nciConceptName":"Anti-CCR8 Monoclonal Antibody GS-1811","termId":806289,"name":"anti-CCR8 monoclonal antibody GS-1811","firstLetter":"a","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"anti-ccr8-monoclonal-antibody-gs-1811"}],"links":null}