{"meta":{"totalResults":1,"from":0},"results":[{"aliases":[{"type":"CodeName","name":"HBM4003"},{"type":"CodeName","name":"HBM-4003"},{"type":"CodeName","name":"HBM 4003"}],"definition":{"html":"A recombinant human heavy chain only antibody (HCAb) directed against the human T-cell-expressed receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4;CTLA4), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-CTLA-4 monoclonal antibody HBM4003 targets and binds to CTLA-4 expressed on T cells, and inhibits the CTLA-4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. In addition, HBM4003 induces an antibody-dependent cell cytotoxicity (ADCC). CTLA-4, an inhibitory receptor and member of the immunoglobulin superfamily (IgSF), plays a key role in the downregulation of the immune system. HBM4003, being a HCAb, is smaller than conventional antibodies which may allow for increased tissue penetration.\n","text":"A recombinant human heavy chain only antibody (HCAb) directed against the human T-cell-expressed receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4;CTLA4), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-CTLA-4 monoclonal antibody HBM4003 targets and binds to CTLA-4 expressed on T cells, and inhibits the CTLA-4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. In addition, HBM4003 induces an antibody-dependent cell cytotoxicity (ADCC). CTLA-4, an inhibitory receptor and member of the immunoglobulin superfamily (IgSF), plays a key role in the downregulation of the immune system. HBM4003, being a HCAb, is smaller than conventional antibodies which may allow for increased tissue penetration.\n"},"drugInfoSummaryLink":null,"nciConceptId":"C173540","nciConceptName":"Porustobart","termId":801868,"name":"anti-CTLA4 monoclonal antibody HBM4003","firstLetter":"a","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"porustobart"}],"links":null}