{"meta":{"totalResults":1,"from":0},"results":[{"aliases":[{"type":"CodeName","name":"IMSA101"},{"type":"CodeName","name":"IMSA-101"},{"type":"CodeName","name":"IMSA 101"}],"definition":{"html":"A small molecule analogue of cyclic GMP-AMP (cGAMP) that acts as an agonist of the stimulator of interferon genes protein (STING; transmembrane protein 173; TMEM173) with potential immunoactivating and antineoplastic activities. Upon intratumoral administration, STING agonist IMSA101 binds to STING and activates STING-mediated pathways. This activates the immune response through the activation of certain immune cells which induces the expression of pro-inflammatory cytokines and chemokines, promotes tumor-associated antigen (TAA) processing and presentation by dendritic cells (DCs) and leads to an antigen-specific T-cell mediated immune response against cancer cells. STING, a transmembrane protein that activates immune cells in the tumor microenvironment, plays a key role in the activation of the innate immune system.\n","text":"A small molecule analogue of cyclic GMP-AMP (cGAMP) that acts as an agonist of the stimulator of interferon genes protein (STING; transmembrane protein 173; TMEM173) with potential immunoactivating and antineoplastic activities. Upon intratumoral administration, STING agonist IMSA101 binds to STING and activates STING-mediated pathways. This activates the immune response through the activation of certain immune cells which induces the expression of pro-inflammatory cytokines and chemokines, promotes tumor-associated antigen (TAA) processing and presentation by dendritic cells (DCs) and leads to an antigen-specific T-cell mediated immune response against cancer cells. STING, a transmembrane protein that activates immune cells in the tumor microenvironment, plays a key role in the activation of the innate immune system.\n"},"drugInfoSummaryLink":null,"nciConceptId":"C165655","nciConceptName":"STING Agonist IMSA101","termId":800118,"name":"STING agonist IMSA101","firstLetter":"s","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"sting-agonist-imsa101"}],"links":null}