{"meta":{"totalResults":1,"from":0},"results":[{"aliases":[{"type":"Synonym","name":"nogapendekin alfa inbakicept"},{"type":"USBrandName","name":"Anktiva"},{"type":"CodeName","name":"ALT 803"},{"type":"CodeName","name":"ALT-803"},{"type":"CodeName","name":"N803"},{"type":"Synonym","name":"superagonist interleukin-15:interleukin-15 receptor alphaSu/Fc fusion complex Alt-803"},{"type":"CodeName","name":"N 803"},{"type":"CodeName","name":"N-803"},{"type":"Synonym","name":"IL-15N72D-IL-15RaSU/Fc"},{"type":"Abbreviation","name":"IL-15N72D/IL-15Ra-Fc"},{"type":"CodeName","name":"ALT803"},{"type":"Synonym","name":"inbakicept nogapendekin alfa fusion complex"}],"definition":{"html":"A mutated form of the cytokine interleukin (IL)-15 (IL-15N72D), with potential immunomodulating and antineoplastic activities. Upon administration, nogapendekin alfa binds to the IL-15 receptor on natural killer (NK) and CD8+ T lymphocytes, which activates and increases the levels of NK cells and memory T cells. This may increase tumor cell killing and decrease tumor cell proliferation. IL-15 regulates CD8+ T and NK cell development, activation and proliferation.","text":"A mutated form of the cytokine interleukin (IL)-15 (IL-15N72D), with potential immunomodulating and antineoplastic activities. Upon administration, nogapendekin alfa binds to the IL-15 receptor on natural killer (NK) and CD8+ T lymphocytes, which activates and increases the levels of NK cells and memory T cells. This may increase tumor cell killing and decrease tumor cell proliferation. IL-15 regulates CD8+ T and NK cell development, activation and proliferation."},"drugInfoSummaryLink":{"uri":"https://www.cancer.gov/about-cancer/treatment/drugs/nogapendekin-alfa-inbakicept-pmln","text":"Nogapendekin Alfa Inbakicept-pmln"},"nciConceptId":"C205507","nciConceptName":"Nogapendekin Alfa Inbakicept","termId":751380,"name":"nogapendekin alfa inbakicept-pmln","firstLetter":"n","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"nogapendekin-alfa-inbakicept"}],"links":null}