{"meta":{"totalResults":1,"from":0},"results":[{"aliases":[{"type":"CodeName","name":"ONO-4578"},{"type":"Synonym","name":"prostaglandin E2 receptor antagonist ONO-4578"},{"type":"Synonym","name":"PGE2 receptor antagonist ONO-4578"},{"type":"Synonym","name":"selective PGE2 receptor 4 antagonist ONO-4578"},{"type":"CodeName","name":"BMS-986310"}],"definition":{"html":"An orally bioavailable antagonist of the prostaglandin E2 receptor subtype 4 (PTGER4; EP4), with potential analgesic, immunomodulating and antineoplastic activities. Upon administration, the EP4 antagonist ONO-4578 selectively targets and binds to EP4, inhibiting the binding of the immunosuppressive prostaglandin E2 (PGE2) to EP4. This prevents the activation of EP4 and inhibits PGE2-EP4-mediated signaling, thereby inhibiting proliferation of tumor cells in which the PGE2-EP4 signaling pathway is over-activated. In addition, EP4 inhibition prevents the activity of tumor-associated myeloid cells (TAMCs) in the tumor microenvironment (TME) by inhibiting interleukin-23 (IL-23) production and the IL-23-mediated expansion of Th17 cells. EP4, a prostanoid receptor, is a G protein-coupled receptor that is expressed in certain types of cancers; it promotes tumor cell proliferation and invasion.","text":"An orally bioavailable antagonist of the prostaglandin E2 receptor subtype 4 (PTGER4; EP4), with potential analgesic, immunomodulating and antineoplastic activities. Upon administration, the EP4 antagonist ONO-4578 selectively targets and binds to EP4, inhibiting the binding of the immunosuppressive prostaglandin E2 (PGE2) to EP4. This prevents the activation of EP4 and inhibits PGE2-EP4-mediated signaling, thereby inhibiting proliferation of tumor cells in which the PGE2-EP4 signaling pathway is over-activated. In addition, EP4 inhibition prevents the activity of tumor-associated myeloid cells (TAMCs) in the tumor microenvironment (TME) by inhibiting interleukin-23 (IL-23) production and the IL-23-mediated expansion of Th17 cells. EP4, a prostanoid receptor, is a G protein-coupled receptor that is expressed in certain types of cancers; it promotes tumor cell proliferation and invasion."},"drugInfoSummaryLink":null,"nciConceptId":"C150376","nciConceptName":"EP4 Antagonist ONO-4578","termId":792745,"name":"EP4 antagonist ONO-4578","firstLetter":"e","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"ep4-antagonist-ono-4578"}],"links":null}