{"meta":{"totalResults":1,"from":0},"results":[{"aliases":[{"type":"CodeName","name":"TNB-486"},{"type":"CodeName","name":"TNB486"},{"type":"CodeName","name":"TNB 486"},{"type":"Synonym","name":"bispecific antibody TNB-486"},{"type":"Synonym","name":"CD19 x CD3 T-BsAb TNB-486"},{"type":"Synonym","name":"anti-CD19/CD3 T-cell engaging bispecific antibody TNB-486"}],"definition":{"html":"A human bispecific T-cell engager antibody composed of a fixed-light-chain (FLC) arm targeting the CD3 antigen found on T lymphocytes and a heavy-chain-only (HCO) arm targeting the B-cell-specific membrane protein CD19, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD19/CD3 bispecific antibody TNB-486 binds to both the CD3 antigen on cytotoxic T lymphocytes (CTLs) and the CD19 antigen expressed on malignant B cells. This activates and redirects CTLs to CD19-expressing tumor cells, resulting in CTL-mediated killing of tumor cells. CD19 is a membrane antigen that is widely expressed during B-cell development, from pro-B-cell to early plasma cell stages. The FLC arm weakly activates CD3. The HCO arm has a high affinity anti-CD19 moiety.","text":"A human bispecific T-cell engager antibody composed of a fixed-light-chain (FLC) arm targeting the CD3 antigen found on T lymphocytes and a heavy-chain-only (HCO) arm targeting the B-cell-specific membrane protein CD19, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD19/CD3 bispecific antibody TNB-486 binds to both the CD3 antigen on cytotoxic T lymphocytes (CTLs) and the CD19 antigen expressed on malignant B cells. This activates and redirects CTLs to CD19-expressing tumor cells, resulting in CTL-mediated killing of tumor cells. CD19 is a membrane antigen that is widely expressed during B-cell development, from pro-B-cell to early plasma cell stages. The FLC arm weakly activates CD3. The HCO arm has a high affinity anti-CD19 moiety."},"drugInfoSummaryLink":null,"nciConceptId":"C178577","nciConceptName":"Surovatamig","termId":804634,"name":"anti-CD19/CD3 bispecific antibody TNB-486","firstLetter":"a","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"surovatamig"}],"links":null}