{"meta":{"totalResults":1,"from":0},"results":[{"aliases":[{"type":"CodeName","name":"TRK-950"},{"type":"CodeName","name":"TRK 950"},{"type":"CodeName","name":"TRK950"}],"definition":{"html":"A humanized monoclonal antibody directed against cell cycle associated protein 1 (cytoplasmic activation- and proliferation-associated protein 1; Caprin-1; CAPRIN1; RNA granule protein 105; RNG105), with potential antineoplastic activity. Upon administration, anti-Caprin-1 monoclonal antibody TRK-950 targets and binds to Caprin-1 expressed on tumor cells. This may induce antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP), thereby killing Caprin-1-expressing tumor cells. Caprin-1 is overexpressed on certain tumor cell types and plays a key role in tumor cell proliferation and metastasis.","text":"A humanized monoclonal antibody directed against cell cycle associated protein 1 (cytoplasmic activation- and proliferation-associated protein 1; Caprin-1; CAPRIN1; RNA granule protein 105; RNG105), with potential antineoplastic activity. Upon administration, anti-Caprin-1 monoclonal antibody TRK-950 targets and binds to Caprin-1 expressed on tumor cells. This may induce antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP), thereby killing Caprin-1-expressing tumor cells. Caprin-1 is overexpressed on certain tumor cell types and plays a key role in tumor cell proliferation and metastasis."},"drugInfoSummaryLink":null,"nciConceptId":"C142826","nciConceptName":"Anti-Caprin-1 Monoclonal Antibody TRK-950","termId":791700,"name":"anti-Caprin-1 monoclonal antibody TRK-950","firstLetter":"a","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"anti-caprin-1-monoclonal-antibody-trk-950"}],"links":null}