{"meta":{"totalResults":1,"from":0},"results":[{"aliases":[{"type":"CodeName","name":"AgenT-797"},{"type":"Synonym","name":"allogeneic iNKT agenT-797"},{"type":"CodeName","name":"AGENT 797"},{"type":"CodeName","name":"agenT797"}],"definition":{"html":"A preparation of allogeneic, off-the shelf, natural killer T cells (NKTs) expressing an invariant (alpha, beta) T-cell receptor (iNKTs), with potential immunomodulating and antineoplastic activities. Upon administration of allogeneic iNKT agenT-797, the invariant T-cell receptor (TCR) and natural-killer group 2, member D receptor (NKG2D; KLRK1; natural killer cell activating receptor group 2D) expressed by these cells recognize CD1d-restricted lipid ligands and stress ligands, which are expressed on certain tumor cells. These receptor-ligand interactions may induce the secretion of large amounts of various pro-inflammatory cytokines, including interferon gamma (IFN-g), and activate the immune system against tumor cells. Additionally, iNKTs directly target and lyse tumor cells.","text":"A preparation of allogeneic, off-the shelf, natural killer T cells (NKTs) expressing an invariant (alpha, beta) T-cell receptor (iNKTs), with potential immunomodulating and antineoplastic activities. Upon administration of allogeneic iNKT agenT-797, the invariant T-cell receptor (TCR) and natural-killer group 2, member D receptor (NKG2D; KLRK1; natural killer cell activating receptor group 2D) expressed by these cells recognize CD1d-restricted lipid ligands and stress ligands, which are expressed on certain tumor cells. These receptor-ligand interactions may induce the secretion of large amounts of various pro-inflammatory cytokines, including interferon gamma (IFN-g), and activate the immune system against tumor cells. Additionally, iNKTs directly target and lyse tumor cells."},"drugInfoSummaryLink":null,"nciConceptId":"C178501","nciConceptName":"Allogeneic Invariant Natural Killer T-cells agenT-797","termId":804944,"name":"allogeneic invariant natural killer T cells agenT-797","firstLetter":"a","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"allogeneic-invariant-natural-killer-t-cells-agent-797"}],"links":null}