{"meta":{"totalResults":1,"from":0},"results":[{"aliases":[{"type":"Synonym","name":"VNC AU-011"},{"type":"Synonym","name":"HPV-NP AU-011"},{"type":"Synonym","name":"light-activated AU-011"},{"type":"Synonym","name":"viral nanoparticle conjugates AU-011"},{"type":"CodeName","name":"AU-011"},{"type":"Synonym","name":"human papillomavirus virus-like particles conjugated with IR700 Dye AU-011"},{"type":"CASRegistryName","name":"2390462-37-8"}],"definition":{"html":"A formulation composed of nanoparticles derived from the human papillomavirus (HPV-NPs) and conjugated to the infrared (IR)-activated fluorescent dye IR700 (IR-700), with potential antineoplastic activity. Upon intravitreal injection of belzupacap sarotalocan, the HPV-NPs target and bind to heparan-sulfated proteoglycans (HSPG) expressed by ocular melanoma cells. Upon irradiation with near-IR (NIR) light, the photosensitizer IR700 becomes activated, generates reactive oxygen species (ROS) and selectively damages the melanoma cell membrane, which induces necrosis of the melanoma cells while sparing the surrounding, healthy non-HSPG-expressing tissue, and potentially preserving vision. HSPGs are overexpressed on a variety of cancer cell types.","text":"A formulation composed of nanoparticles derived from the human papillomavirus (HPV-NPs) and conjugated to the infrared (IR)-activated fluorescent dye IR700 (IR-700), with potential antineoplastic activity. Upon intravitreal injection of belzupacap sarotalocan, the HPV-NPs target and bind to heparan-sulfated proteoglycans (HSPG) expressed by ocular melanoma cells. Upon irradiation with near-IR (NIR) light, the photosensitizer IR700 becomes activated, generates reactive oxygen species (ROS) and selectively damages the melanoma cell membrane, which induces necrosis of the melanoma cells while sparing the surrounding, healthy non-HSPG-expressing tissue, and potentially preserving vision. HSPGs are overexpressed on a variety of cancer cell types."},"drugInfoSummaryLink":null,"nciConceptId":"C137951","nciConceptName":"Belzupacap Sarotalocan","termId":790618,"name":"belzupacap sarotalocan","firstLetter":"b","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"belzupacap-sarotalocan"}],"links":null}