{"meta":{"totalResults":5,"from":0},"results":[{"aliases":[{"type":"Abbreviation","name":"b-GLUC"},{"type":"USBrandName","name":"Immucell WGP"}],"definition":{"html":"A polysaccharide isolated from the cell walls of bacteria, plants, and fungi with immunostimulant and antineoplastic activities. In a solubilized form, beta-glucan binds to a lectin site within complement receptor 3 (CR3) on leukocytes, priming the receptor to trigger cytotoxic degranulation of leukocytes when leukocyte CR3 binds to complement 3 (iC3b)-coated tumors. Thus, the attachment of beta-glucan to CR3 of circulating leukocytes simulates leukocytes to kill iC3b-coated tumor cells in the same way as they kill iC3b-coated yeast.","text":"A polysaccharide isolated from the cell walls of bacteria, plants, and fungi with immunostimulant and antineoplastic activities. In a solubilized form, beta-glucan binds to a lectin site within complement receptor 3 (CR3) on leukocytes, priming the receptor to trigger cytotoxic degranulation of leukocytes when leukocyte CR3 binds to complement 3 (iC3b)-coated tumors. Thus, the attachment of beta-glucan to CR3 of circulating leukocytes simulates leukocytes to kill iC3b-coated tumor cells in the same way as they kill iC3b-coated yeast."},"drugInfoSummaryLink":null,"nciConceptId":"C2678","nciConceptName":"Beta-Glucan","termId":38642,"name":"beta-glucan","firstLetter":"b","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"beta-glucan"},{"aliases":[{"type":"CodeName","name":"MM-10-001"}],"definition":{"html":"A powder formulation containing a triple helix beta-glucan, isolated from the cell walls of the shiitake mushroom (Lentinula edodes), with potential immunostimulating activity.  The beta-glucan in beta-glucan MM-10-001 binds to a lectin site within the complement receptor 3 (CR3 or iC3b receptor) on leukocytes, priming the receptor to trigger cytotoxic degranulation of leukocytes when leukocyte CR3 binds to iC3b-opsonized  tumor cells. iC3b is the proteolyticly inactive product of the complement cleavage fragment C3b.","text":"A powder formulation containing a triple helix beta-glucan, isolated from the cell walls of the shiitake mushroom (Lentinula edodes), with potential immunostimulating activity.  The beta-glucan in beta-glucan MM-10-001 binds to a lectin site within the complement receptor 3 (CR3 or iC3b receptor) on leukocytes, priming the receptor to trigger cytotoxic degranulation of leukocytes when leukocyte CR3 binds to iC3b-opsonized  tumor cells. iC3b is the proteolyticly inactive product of the complement cleavage fragment C3b."},"drugInfoSummaryLink":null,"nciConceptId":"C82657","nciConceptName":"Beta-Glucan MM-10-001","termId":636186,"name":"beta-glucan MM-10-001","firstLetter":"b","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"beta-glucan-mm-10-001"},{"aliases":[{"type":"ForeignBrandName","name":"Neoviderm"}],"definition":{"html":"A topical emulsion containing beta-glucan (5%), alginate, hyaluronic acid, squalene and avocado oil, with cutaneous protective activity. Upon topical application of beta-glucan/alginate/hyaluronic acid/squalene/avocado oil-containing emulsion, the naturally-occurring polysaccharide beta-glucan acts as an immunomodulator by activating the innate immune response, in particular through the activation of macrophages and migration of neutrophils. Alginate acts as a moisturizer and supports skin healing. Hyaluronic acid, squalene and avocado oil provide barrier protection, help maintain skin integrity and are natural emollients and moisturizers. This emulsion may accelerate wound healing and may prevent radiation-induced dermatitis.","text":"A topical emulsion containing beta-glucan (5%), alginate, hyaluronic acid, squalene and avocado oil, with cutaneous protective activity. Upon topical application of beta-glucan/alginate/hyaluronic acid/squalene/avocado oil-containing emulsion, the naturally-occurring polysaccharide beta-glucan acts as an immunomodulator by activating the innate immune response, in particular through the activation of macrophages and migration of neutrophils. Alginate acts as a moisturizer and supports skin healing. Hyaluronic acid, squalene and avocado oil provide barrier protection, help maintain skin integrity and are natural emollients and moisturizers. This emulsion may accelerate wound healing and may prevent radiation-induced dermatitis."},"drugInfoSummaryLink":null,"nciConceptId":"C99170","nciConceptName":"Beta-glucan/Alginate/Hyaluronic Acid/Squalene/Avocado Oil-containing Emulsion","termId":717605,"name":"beta-glucan/alginate/hyaluronic acid/squalene/avocado oil-containing emulsion","firstLetter":"b","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":""},{"aliases":[{"type":"Synonym","name":"beta-glucan/dexpanthenol/glutamine in Mucolox (TM)"}],"definition":{"html":"A water soluble, hydrogel-based formulation containing beta-glucan, a polysaccharide isolated from the cell walls of bacteria, plants, and fungi, dexpanthenol, an alcohol derivative of pantothenic acid, the nonessential amino acid glutamine, and preserved water, that can potentially be used to treat mucositis. Upon oral administration of the beta-glucan/dexpanthenol/glutamine in mucoadhesive polymer hydrogel, the mucoadhesive polymer hydrogel interacts with the oral mucosa and promotes contact time between the active ingredients and the mucous membranes in the mouth while also providing moisture and serving as a protective barrier. The additional preserved water may also keep the oral mucosa moisturized. Dexpanthenol is converted to pantothenic acid (vitamin B5) which is required for coenzyme A synthesis as well as for the metabolism of proteins, carbohydrates, and fats. Coenzyme A is involved in fatty acids and sphingolipids synthesis crucial for cell membrane integrity. Dexpanthenol may promote cell proliferation and epithelial remodeling and may provide a protective and healing effect on the oral mucosa. Beta-glucan may stimulate the immune system, may protect against pathogens and may prevent inflammation. Glutamine may also help maintain the integrity of the oral mucosa, prevent cellular damage, and improve cellular recovery. Altogether, this may prevent or reduce radiation/chemotherapy-induced mucositis.","text":"A water soluble, hydrogel-based formulation containing beta-glucan, a polysaccharide isolated from the cell walls of bacteria, plants, and fungi, dexpanthenol, an alcohol derivative of pantothenic acid, the nonessential amino acid glutamine, and preserved water, that can potentially be used to treat mucositis. Upon oral administration of the beta-glucan/dexpanthenol/glutamine in mucoadhesive polymer hydrogel, the mucoadhesive polymer hydrogel interacts with the oral mucosa and promotes contact time between the active ingredients and the mucous membranes in the mouth while also providing moisture and serving as a protective barrier. The additional preserved water may also keep the oral mucosa moisturized. Dexpanthenol is converted to pantothenic acid (vitamin B5) which is required for coenzyme A synthesis as well as for the metabolism of proteins, carbohydrates, and fats. Coenzyme A is involved in fatty acids and sphingolipids synthesis crucial for cell membrane integrity. Dexpanthenol may promote cell proliferation and epithelial remodeling and may provide a protective and healing effect on the oral mucosa. Beta-glucan may stimulate the immune system, may protect against pathogens and may prevent inflammation. Glutamine may also help maintain the integrity of the oral mucosa, prevent cellular damage, and improve cellular recovery. Altogether, this may prevent or reduce radiation/chemotherapy-induced mucositis."},"drugInfoSummaryLink":null,"nciConceptId":"C209811","nciConceptName":"Beta-glucan/Dexpanthenol/Glutamine in Mucoadhesive Polymer Hydrogel","termId":817538,"name":"beta-glucan/dexpanthenol/glutamine in mucoadhesive polymer hydrogel","firstLetter":"b","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"beta-glucan-dexpanthenol-glutamine-in-mucoadhesive-polymer-hydrogel"},{"aliases":[{"type":"ForeignBrandName","name":"Citogenex"}],"definition":{"html":"A synbiotic supplement containing beta-1,3-glucan, bacteria Lactobacillus casei (L. casei) and Bifidobacterium lactis (B. lactis), with potential immunomodulating activity. The naturally-occurring bacterial components in this dietary supplement may improve digestion and help maintain adequate colonization of the gastrointestinal (GI) tract by modulating the composition of the normal microflora. During colonization of the GI tract, the bacteria may form a protective intestinal barrier, thereby preventing attachment of potential pathogens. Both the probiotics and beta-glucan have been shown to stimulate the immune system. This supplement also contains several vitamins and other insoluble polysaccharides.","text":"A synbiotic supplement containing beta-1,3-glucan, bacteria Lactobacillus casei (L. casei) and Bifidobacterium lactis (B. lactis), with potential immunomodulating activity. The naturally-occurring bacterial components in this dietary supplement may improve digestion and help maintain adequate colonization of the gastrointestinal (GI) tract by modulating the composition of the normal microflora. During colonization of the GI tract, the bacteria may form a protective intestinal barrier, thereby preventing attachment of potential pathogens. Both the probiotics and beta-glucan have been shown to stimulate the immune system. This supplement also contains several vitamins and other insoluble polysaccharides."},"drugInfoSummaryLink":null,"nciConceptId":"C99227","nciConceptName":"Beta-glucan/Lactobacillus casei/Bifidobacterium lactis-based Supplement","termId":719078,"name":"beta-glucan/Lactobacillus casei/Bifidobacterium lactis-based supplement","firstLetter":"b","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"beta-glucan-lactobacillus-casei-bifidobacterium-lactis-based-supplement"}],"links":null}