{"meta":{"totalResults":1,"from":0},"results":[{"aliases":[{"type":"USBrandName","name":"Jevtana"},{"type":"Synonym","name":"taxoid XRP6258"},{"type":"CodeName","name":"XRP6258"},{"type":"CodeName","name":"XRP-6258"},{"type":"CodeName","name":"RPR-116258A"},{"type":"CodeName","name":"RPR116258A"},{"type":"CodeName","name":"TXD258"},{"type":"ChemicalStructureName","name":"1-hydroxy-7beta,10beta-dimethoxy-9-oxo-5beta,20-epoxytax-11-ene-2alpha,4,13alpha-triyl 4-acetate 2-benzoate 13-[(2R,3S)-3-{[(tertbutoxy)carbonyl]amino}-2-hydroxy-3-phenylpropanoate]"},{"type":"CASRegistryName","name":"183133-96-2"}],"definition":{"html":"A semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance (MDR), P-glycoprotein (P-gp) efflux pump and may be useful for treating multidrug-resistant tumors. In addition, cabazitaxel penetrates the blood-brain barrier (BBB).","text":"A semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance (MDR), P-glycoprotein (P-gp) efflux pump and may be useful for treating multidrug-resistant tumors. In addition, cabazitaxel penetrates the blood-brain barrier (BBB)."},"drugInfoSummaryLink":{"uri":"https://www.cancer.gov/about-cancer/treatment/drugs/cabazitaxel","text":"Cabazitaxel"},"nciConceptId":"C66937","nciConceptName":"Cabazitaxel","termId":534131,"name":"cabazitaxel","firstLetter":"c","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"cabazitaxel"}],"links":null}