{"meta":{"totalResults":1,"from":0},"results":[{"aliases":[{"type":"CodeName","name":"CG0070"},{"type":"Synonym","name":"oncolytic adenovirus encoding GM-CSF"},{"type":"CASRegistryName","name":"2414312-87-9"},{"type":"CodeName","name":"CG 0070"},{"type":"CodeName","name":"CG-0070"}],"definition":{"html":"A recombinant oncolytic adenovirus encoding the immunohematopoietic cytokine granulocyte-macrophage colony stimulating factor (GM-CSF) with potential antineoplastic activity. Upon administration, cretostimogene grenadenorepvec selectively infects and replicates in tumor cells, which may result in tumor cells lysis. Synergistically, GM-CSF expressed by the oncolytic adenovirus may promote a cytotoxic T cell response against tumor cells harboring the oncolytic adenovirus, resulting in an immune-mediated tumor cell death.","text":"A recombinant oncolytic adenovirus encoding the immunohematopoietic cytokine granulocyte-macrophage colony stimulating factor (GM-CSF) with potential antineoplastic activity. Upon administration, cretostimogene grenadenorepvec selectively infects and replicates in tumor cells, which may result in tumor cells lysis. Synergistically, GM-CSF expressed by the oncolytic adenovirus may promote a cytotoxic T cell response against tumor cells harboring the oncolytic adenovirus, resulting in an immune-mediated tumor cell death."},"drugInfoSummaryLink":null,"nciConceptId":"C48412","nciConceptName":"Cretostimogene Grenadenorepvec","termId":434519,"name":"cretostimogene grenadenorepvec","firstLetter":"c","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"cretostimogene-grenadenorepvec"}],"links":null}