{"meta":{"totalResults":3,"from":0},"results":[{"aliases":[{"type":"ChemicalStructureName","name":"2-(difluoromethyl)-DL-ornithine"},{"type":"ChemicalStructureName","name":"2-difluoromethylornithine"},{"type":"CASRegistryName","name":"70052-12-9"},{"type":"Synonym","name":"alpha-difluoromethylornithine"},{"type":"ChemicalStructureName","name":"D,L-alpha-difluoromethylornithine"},{"type":"Abbreviation","name":"DFMO"},{"type":"Synonym","name":"difluoromethylornithine"},{"type":"Synonym","name":"difluromethylornithine"}],"definition":{"html":"A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. This agent has been shown to induce apoptosis in leiomyoma cells.","text":"A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. This agent has been shown to induce apoptosis in leiomyoma cells."},"drugInfoSummaryLink":null,"nciConceptId":"C226","nciConceptName":"Eflornithine","termId":818462,"name":"eflornithine","firstLetter":"e","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"eflornithine"},{"aliases":[{"type":"USBrandName","name":"Iwilfin"},{"type":"Synonym","name":"eflornithine HCl"},{"type":"ChemicalStructureName","name":"2-(difluoromethyl)-DL-ornithine hydrochloride, monohydrate"},{"type":"Synonym","name":"2-difluoromethylornithine hydrochloride"},{"type":"Synonym","name":"alpha-difluoromethylornithine hydrochloride"},{"type":"CodeName","name":"MDL 71782"},{"type":"ObsoleteName","name":"Ornidyl"},{"type":"CodeName","name":"RMI-71782"},{"type":"CASRegistryName","name":"96020-91-6"},{"type":"ChemicalStructureName","name":"2-difluoromethyl-dl-ornithine, monohydrochloride, monohydrate"},{"type":"USBrandName","name":"Vaniqa"}],"definition":{"html":"The hydrochloride form of eflornithine, a difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells.","text":"The hydrochloride form of eflornithine, a difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells."},"drugInfoSummaryLink":{"uri":"https://www.cancer.gov/about-cancer/treatment/drugs/eflornithine-hydrochloride","text":"Eflornithine Hydrochloride"},"nciConceptId":"C1579","nciConceptName":"Eflornithine Hydrochloride","termId":39754,"name":"eflornithine hydrochloride","firstLetter":"e","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"eflornithine-hydrochloride"},{"aliases":[{"type":"Synonym","name":"DL-alpha-difluoromethylornitine hydrochloride ointment"}],"definition":{"html":"An ointment formulation of the hydrochloride salt of an ornithine decarboxylase (ODC) inhibitor with hair-growth inhibitory and potential  chemopreventive activities. When administered topically, eflornithine irreversibly inhibits skin ODC activity, thereby inhibiting the synthesis of polyamines; inhibition of polyamine synthesis may result in diminished hair growth and epidermal cell turnover.\n","text":"An ointment formulation of the hydrochloride salt of an ornithine decarboxylase (ODC) inhibitor with hair-growth inhibitory and potential  chemopreventive activities. When administered topically, eflornithine irreversibly inhibits skin ODC activity, thereby inhibiting the synthesis of polyamines; inhibition of polyamine synthesis may result in diminished hair growth and epidermal cell turnover.\n"},"drugInfoSummaryLink":null,"nciConceptId":"C74026","nciConceptName":"Eflornithine Hydrochloride Ointment","termId":585656,"name":"eflornithine hydrochloride ointment","firstLetter":"e","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"eflornithine-hydrochloride-ointment"}],"links":null}