{"meta":{"totalResults":1,"from":0},"results":[{"aliases":[{"type":"Synonym","name":"enfortumab vedotin"},{"type":"CodeName","name":"ASG-22CE"},{"type":"Synonym","name":"anti-nectin 4 ADC ASG-22CE"},{"type":"USBrandName","name":"Padcev"},{"type":"CASRegistryName","name":"1346452-25-2"},{"type":"CodeName","name":"AGS 22ME"},{"type":"CodeName","name":"AGS-22M6E"},{"type":"Synonym","name":"anti-nectin-4 monoclonal antibody-drug conjugate AGS-22M6E"}],"definition":{"html":"An antibody drug conjugate (ADC) containing a human monoclonal antibody AGS-22 targeting the cell adhesion molecule nectin-4 and conjugated to the cytotoxic agent monomethyl auristatin E (MMAE), via a proprietary enzyme-cleavable linker (AGS-22CE), with potential antineoplastic activity. The monoclonal antibody moiety of enfortumab vedotin-ejfv electively binds to nectin-4. After internalization and proteolytic cleavage, MMAE binds to tubulin and inhibits its polymerization, which results in G2/M phase arrest and induces apoptosis in nectin-4 overexpressing tumor cells. Nectin-4, a tumor associated antigen belonging to the nectin family, is overexpressed in a variety of cancers, including breast, bladder, lung and pancreatic cancer.","text":"An antibody drug conjugate (ADC) containing a human monoclonal antibody AGS-22 targeting the cell adhesion molecule nectin-4 and conjugated to the cytotoxic agent monomethyl auristatin E (MMAE), via a proprietary enzyme-cleavable linker (AGS-22CE), with potential antineoplastic activity. The monoclonal antibody moiety of enfortumab vedotin-ejfv electively binds to nectin-4. After internalization and proteolytic cleavage, MMAE binds to tubulin and inhibits its polymerization, which results in G2/M phase arrest and induces apoptosis in nectin-4 overexpressing tumor cells. Nectin-4, a tumor associated antigen belonging to the nectin family, is overexpressed in a variety of cancers, including breast, bladder, lung and pancreatic cancer."},"drugInfoSummaryLink":{"uri":"https://www.cancer.gov/about-cancer/treatment/drugs/enfortumabvedotin-ejfv","text":"Enfortumab Vedotin-ejfv"},"nciConceptId":"C114500","nciConceptName":"Enfortumab Vedotin","termId":759429,"name":"enfortumab vedotin-ejfv","firstLetter":"e","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"enfortumab-vedotin"}],"links":null}