{"meta":{"totalResults":1,"from":0},"results":[{"aliases":[{"type":"Abbreviation","name":"2-F-ara-AMP"},{"type":"ObsoleteName","name":"Fludara"},{"type":"ForeignBrandName","name":"Beneflur"},{"type":"ChemicalStructureName","name":"9H-purin-6-amine, 2-fluoro-9-(5-O-phosphono-.beta.-D-arabinofuranosyl)"},{"type":"ChemicalStructureName","name":"fludarabine-5'-monophosphate"},{"type":"ObsoleteName","name":"Oforta"},{"type":"CodeName","name":"SH T 586"},{"type":"CASRegistryName","name":"75607-67-9"},{"type":"ChemicalStructureName","name":"9H-purin-6-amine, 2-fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)"}],"definition":{"html":"The phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth.","text":"The phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth."},"drugInfoSummaryLink":{"uri":"https://www.cancer.gov/about-cancer/treatment/drugs/fludarabinephosphate","text":"Fludarabine Phosphate"},"nciConceptId":"C1102","nciConceptName":"Fludarabine Phosphate","termId":39244,"name":"fludarabine phosphate","firstLetter":"f","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"fludarabine-phosphate"}],"links":null}