{"meta":{"totalResults":1,"from":0},"results":[{"aliases":[{"type":"Abbreviation","name":"HU"},{"type":"Synonym","name":"HYD"},{"type":"USBrandName","name":"Hydrea"},{"type":"Synonym","name":"Hydroxycarbamide"},{"type":"Synonym","name":"Hydurea"},{"type":"ForeignBrandName","name":"Litalir"},{"type":"USBrandName","name":"Droxia"},{"type":"ForeignBrandName","name":"Onco-Carbide"},{"type":"LexicalVariant","name":"Oncocarbide"},{"type":"ForeignBrandName","name":"Oxeron"},{"type":"CodeName","name":"SQ-1089"},{"type":"CodeName","name":"SQ 1089"},{"type":"ForeignBrandName","name":"Syrea"},{"type":"CodeName","name":"WR 83799"},{"type":"INDCode","name":"9235"},{"type":"INDCode","name":"937"},{"type":"INDCode","name":"38558"},{"type":"INDCode","name":"7179"},{"type":"NSCNumber","name":"32065"},{"type":"CASRegistryName","name":"127-07-1"}],"definition":{"html":"A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle.  This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair.","text":"A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle.  This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair."},"drugInfoSummaryLink":{"uri":"https://www.cancer.gov/about-cancer/treatment/drugs/hydroxyurea","text":"Hydroxyurea"},"nciConceptId":"C560","nciConceptName":"Hydroxyurea","termId":40685,"name":"hydroxyurea","firstLetter":"h","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"hydroxyurea"}],"links":null}