{"meta":{"totalResults":1,"from":0},"results":[{"aliases":[{"type":"Synonym","name":"BCMA x CD3 bispecific antibody REGN5458"},{"type":"CodeName","name":"REGN5458"},{"type":"Synonym","name":"anti-BCMA/CD3 bispecific antibody REGN5458"},{"type":"CodeName","name":"REGN 5458"},{"type":"Synonym","name":"anti-BCMA x anti-CD3 bispecific antibody REGN5458"},{"type":"CASRegistryName","name":"2408319-25-3"},{"type":"CodeName","name":"REGN-5458"},{"type":"ForeignBrandName","name":"Lynozyfic"}],"definition":{"html":"A human, immunoglobulin G4 (IgG4) bispecific antibody directed against the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and the T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration, linvoseltamab targets and binds to both CD3 on cytotoxic T lymphocytes (CTLs) and BCMA on BCMA-expressing tumor cells. This activates and redirects CTLs to BCMA-expressing tumor cells, leading to CTL-mediated killing of BCMA-expressing tumor cells. BCMA, a member of the tumor necrosis factor receptor superfamily that is specifically overexpressed on malignant plasma cells, plays a key role in promoting plasma cell survival.","text":"A human, immunoglobulin G4 (IgG4) bispecific antibody directed against the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and the T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration, linvoseltamab targets and binds to both CD3 on cytotoxic T lymphocytes (CTLs) and BCMA on BCMA-expressing tumor cells. This activates and redirects CTLs to BCMA-expressing tumor cells, leading to CTL-mediated killing of BCMA-expressing tumor cells. BCMA, a member of the tumor necrosis factor receptor superfamily that is specifically overexpressed on malignant plasma cells, plays a key role in promoting plasma cell survival."},"drugInfoSummaryLink":null,"nciConceptId":"C158504","nciConceptName":"Linvoseltamab","termId":797141,"name":"linvoseltamab","firstLetter":"l","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"linvoseltamab"}],"links":null}