{"meta":{"totalResults":1,"from":0},"results":[{"aliases":[{"type":"CodeName","name":"PM01183"},{"type":"USBrandName","name":"Zepzelca"},{"type":"CASRegistryName","name":"497871-47-3"},{"type":"CodeName","name":"PM-01183"}],"definition":{"html":"A synthetic tetrahydropyrrolo [4, 3, 2-de]quinolin-8(1H)-one alkaloid analogue with potential antineoplastic activity. Lurbinectedin covalently binds to residues lying in the minor groove of DNA, which may result in delayed progression through S phase, cell cycle arrest in the G2/M phase and cell death.","text":"A synthetic tetrahydropyrrolo [4, 3, 2-de]quinolin-8(1H)-one alkaloid analogue with potential antineoplastic activity. Lurbinectedin covalently binds to residues lying in the minor groove of DNA, which may result in delayed progression through S phase, cell cycle arrest in the G2/M phase and cell death."},"drugInfoSummaryLink":{"uri":"https://www.cancer.gov/about-cancer/treatment/drugs/lurbinectedin","text":"Lurbinectedin"},"nciConceptId":"C82382","nciConceptName":"Lurbinectedin","termId":641468,"name":"lurbinectedin","firstLetter":"l","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"lurbinectedin"}],"links":null}