{"meta":{"totalResults":1,"from":0},"results":[{"aliases":[{"type":"Synonym","name":"lutetium-177-PSMA-617"},{"type":"Synonym","name":"lutetium Lu 177-PSMA-617"},{"type":"Synonym","name":"177Lu-PSMA-617"},{"type":"USBrandName","name":"Pluvicto"},{"type":"Synonym","name":"177Lu-labeled PSMA-617"},{"type":"Synonym","name":"Lu177-PSMA-617"},{"type":"CodeName","name":"AAA-617"},{"type":"CodeName","name":"AAA617"},{"type":"CodeName","name":"AAA 617"},{"type":"CASRegistryName","name":"1703749-62-5"}],"definition":{"html":"A radioconjugate composed of PSMA-617, a human prostate-specific membrane antigen (PSMA)-targeting ligand, conjugated to the beta-emitting radioisotope lutetium Lu 177 (177Lu), with potential antineoplastic activity against PSMA-expressing tumor cells. Upon intravenous administration of lutetium Lu 177  vipivotide tetraxetan, vipivotide tetraxetan targets and binds to PSMA-expressing tumor cells. Upon binding, PSMA-expressing tumor cells are destroyed by 177Lu through the specific delivery of beta particle radiation. PSMA, a tumor-associated antigen and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells.","text":"A radioconjugate composed of PSMA-617, a human prostate-specific membrane antigen (PSMA)-targeting ligand, conjugated to the beta-emitting radioisotope lutetium Lu 177 (177Lu), with potential antineoplastic activity against PSMA-expressing tumor cells. Upon intravenous administration of lutetium Lu 177  vipivotide tetraxetan, vipivotide tetraxetan targets and binds to PSMA-expressing tumor cells. Upon binding, PSMA-expressing tumor cells are destroyed by 177Lu through the specific delivery of beta particle radiation. PSMA, a tumor-associated antigen and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells."},"drugInfoSummaryLink":{"uri":"https://www.cancer.gov/about-cancer/treatment/drugs/lutetium-Lu-177-vipivotide-tetraxetan","text":"Lutetium Lu 177 Vipivotide Tetraxetan"},"nciConceptId":"C148145","nciConceptName":"Lutetium Lu 177 Vipivotide Tetraxetan","termId":792497,"name":"lutetium Lu 177 vipivotide tetraxetan","firstLetter":"l","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"lutetium-lu-177-vipivotide-tetraxetan"}],"links":null}