{"meta":{"totalResults":1,"from":0},"results":[{"aliases":[{"type":"Synonym","name":"mosunetuzumab"},{"type":"Synonym","name":"CD20/CD3 BiMAb BTCT4465A"},{"type":"Synonym","name":"anti-CD20 x anti-CD3 bispecific monoclonal antibody BTCT4465A"},{"type":"CodeName","name":"RG7828"},{"type":"CodeName","name":"BTCT 4465A"},{"type":"CodeName","name":"BTCT-4465A"},{"type":"CodeName","name":"RG 7828"},{"type":"USBrandName","name":"Lunsumio"},{"type":"CASRegistryName","name":"1905409-39-3"},{"type":"CodeName","name":"BTCT4465A"},{"type":"CodeName","name":"RG-7828"},{"type":"CodeName","name":"RO7030816"}],"definition":{"html":"A bispecific, humanized monoclonal antibody with potential antineoplastic activity. Mosunetuzumab contains two antigen-recognition sites: one for human CD3, a T-cell surface antigen, and one for human CD20, a tumor-associated antigen (TAA) that is exclusively expressed on B cells during most stages of B-cell development and is often overexpressed in B-cell malignancies. Upon administration, mosunetuzumab binds to both T cells and CD20-expressing tumor B cells; this cross-links T cells to tumor cells, and may result in a potent cytotoxic T-lymphocyte (CTL) response against CD20-expressing tumor B cells.","text":"A bispecific, humanized monoclonal antibody with potential antineoplastic activity. Mosunetuzumab contains two antigen-recognition sites: one for human CD3, a T-cell surface antigen, and one for human CD20, a tumor-associated antigen (TAA) that is exclusively expressed on B cells during most stages of B-cell development and is often overexpressed in B-cell malignancies. Upon administration, mosunetuzumab binds to both T cells and CD20-expressing tumor B cells; this cross-links T cells to tumor cells, and may result in a potent cytotoxic T-lymphocyte (CTL) response against CD20-expressing tumor B cells."},"drugInfoSummaryLink":{"uri":"https://www.cancer.gov/about-cancer/treatment/drugs/mosunetuzumab-axgb","text":"Mosunetuzumab-axgb"},"nciConceptId":"C129691","nciConceptName":"Mosunetuzumab","termId":774847,"name":"mosunetuzumab-axgb","firstLetter":"m","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"mosunetuzumab"}],"links":null}