{"meta":{"totalResults":1,"from":0},"results":[{"aliases":[{"type":"CodeName","name":"DS-6000"},{"type":"CodeName","name":"DS-6000a"},{"type":"Synonym","name":"anti-CDH6 ADC DS-6000a"},{"type":"Synonym","name":"anti-CDH-6 ADC DS-6000a"},{"type":"Synonym","name":"anti-CDH6/DXd ADC DS-6000a"},{"type":"CodeName","name":"DS 6000a"},{"type":"CodeName","name":"DS6000a"},{"type":"CASRegistryName","name":"2610074-57-0"},{"type":"Synonym","name":"anti-CDH6 antibody-drug conjugate DS-6000a"}],"definition":{"html":"An antibody-drug conjugate (ADC) composed of a humanized immunoglobulin G1 (IgG1) monoclonal antibody against the tumor-associated antigen (TAA) cadherin-6 (CDH6; CDH-6) conjugated to deruxtecan, which is comprised of an enzymatically cleavable tetrapeptide-based linker and MAAA-1181a (DXd), the cytotoxic DNA topoisomerase I inhibitor derivative of exatecan, with potential antineoplastic activity. Upon administration of raludotatug deruxtecan, raludotatug targets and binds to CDH6-expressing tumor cells. Upon cellular uptake and lysosomal degradation of the linker, DXd targets and binds to DNA topoisomerase I, thereby stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks, inhibition of DNA replication and apoptosis. This inhibits the proliferation of CDH6-expressing tumor cells. CDH6, a member of the cadherin family and overexpressed by a variety of cancers, plays a key role in tumor cell proliferation.","text":"An antibody-drug conjugate (ADC) composed of a humanized immunoglobulin G1 (IgG1) monoclonal antibody against the tumor-associated antigen (TAA) cadherin-6 (CDH6; CDH-6) conjugated to deruxtecan, which is comprised of an enzymatically cleavable tetrapeptide-based linker and MAAA-1181a (DXd), the cytotoxic DNA topoisomerase I inhibitor derivative of exatecan, with potential antineoplastic activity. Upon administration of raludotatug deruxtecan, raludotatug targets and binds to CDH6-expressing tumor cells. Upon cellular uptake and lysosomal degradation of the linker, DXd targets and binds to DNA topoisomerase I, thereby stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks, inhibition of DNA replication and apoptosis. This inhibits the proliferation of CDH6-expressing tumor cells. CDH6, a member of the cadherin family and overexpressed by a variety of cancers, plays a key role in tumor cell proliferation."},"drugInfoSummaryLink":null,"nciConceptId":"C179214","nciConceptName":"Raludotatug Deruxtecan","termId":804812,"name":"raludotatug deruxtecan","firstLetter":"r","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"raludotatug-deruxtecan"}],"links":null}