{"meta":{"totalResults":1,"from":0},"results":[{"aliases":[{"type":"Synonym","name":"anti-VEGFR-2 fully human monoclonal antibody IMC-1121B"},{"type":"CodeName","name":"IMC-1121B"},{"type":"CodeName","name":"LY3009806"},{"type":"ChemicalStructureName","name":"immunoglobulin G1, anti-(human vascular endothelial growth factor receptor type VEGFR-2 extracellular domain) (human monoclonal IMC-1121B γ-chain), disulfide with human monoclonal IMC-1121B κ-chain, dimer"},{"type":"ChemicalStructureName","name":"immunoglobulin G1, anti-(vascular endothelial growth factor receptor 2 (EC 2.7.10.1 or protein-tyrosine kinase receptor Flk-1 or CD309 antigen) extracellular domain); human monoclonal IMC-1121B γ1 heavy chain (219-214')-disulfide with human monoclonal IMC-1121B κ light chain (225-225'':228-228'')-bisdisulfide dimer"},{"type":"USBrandName","name":"Cyramza"},{"type":"CASRegistryName","name":"947687-13-0"},{"type":"Synonym","name":"monoclonal antibody HGS-ETR2"}],"definition":{"html":"A recombinant, fully human monoclonal antibody directed against human vascular endothelial growth factor receptor 2 (VEGFR-2) with antiangiogenesis activity. Ramucirumab specifically binds to and inhibits VEGFR-2, which may result in an inhibition of tumor angiogenesis and a decrease in tumor nutrient supply. VEGFR-2 is a pro-angiogenic growth factor receptor tyrosine kinase expressed by endothelial cells.","text":"A recombinant, fully human monoclonal antibody directed against human vascular endothelial growth factor receptor 2 (VEGFR-2) with antiangiogenesis activity. Ramucirumab specifically binds to and inhibits VEGFR-2, which may result in an inhibition of tumor angiogenesis and a decrease in tumor nutrient supply. VEGFR-2 is a pro-angiogenic growth factor receptor tyrosine kinase expressed by endothelial cells."},"drugInfoSummaryLink":{"uri":"https://www.cancer.gov/about-cancer/treatment/drugs/ramucirumab","text":"Ramucirumab"},"nciConceptId":"C70792","nciConceptName":"Ramucirumab","termId":570535,"name":"ramucirumab","firstLetter":"r","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"ramucirumab"}],"links":null}