{"meta":{"totalResults":2,"from":0},"results":[{"aliases":[{"type":"USBrandName","name":"Kisqali"},{"type":"CASRegistryName","name":"1374639-75-4"}],"definition":{"html":"The succinate salt form of ribociclib, an orally available inhibitor of the cyclin-dependent kinases (CDKs) 4 and 6, with antineoplastic activity. Upon oral administration, ribociclib specifically targets, binds to and inhibits CDK4 and CDK6. This inhibits the cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, which inhibits phosphorylation of the retinoblastoma (Rb) protein. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle dysregulation.","text":"The succinate salt form of ribociclib, an orally available inhibitor of the cyclin-dependent kinases (CDKs) 4 and 6, with antineoplastic activity. Upon oral administration, ribociclib specifically targets, binds to and inhibits CDK4 and CDK6. This inhibits the cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, which inhibits phosphorylation of the retinoblastoma (Rb) protein. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle dysregulation."},"drugInfoSummaryLink":{"uri":"https://www.cancer.gov/about-cancer/treatment/drugs/ribociclib","text":"Ribociclib Succinate"},"nciConceptId":"C152210","nciConceptName":"Ribociclib Succinate","termId":689330,"name":"ribociclib succinate","firstLetter":"r","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"ribociclib-succinate"},{"aliases":[{"type":"Synonym","name":"ribociclib/letrozole"},{"type":"Synonym","name":"Kisqali and Femara co-pack"},{"type":"USBrandName","name":"Kisqali Femara Co-Pack"},{"type":"Synonym","name":"Kisqali/Femara"},{"type":"Synonym","name":"ribociclib succinate + letrozole"},{"type":"Synonym","name":"ribociclib succinate and letrozole co-pack"},{"type":"Synonym","name":"ribociclib succinate plus letrozole"},{"type":"Synonym","name":"ribociclib succinate-letrozole"},{"type":"Synonym","name":"ribociclib succinate-letrozole regimen"}],"definition":{"html":"An orally available co-packaged agent combination of the succinate salt form of ribociclib, a cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6, and letrozole, a nonsteroidal inhibitor of estrogen synthesis, with antineoplastic activity. Upon oral administration, ribociclib specifically inhibits CDK4 and CDK6, thereby inhibiting retinoblastoma (Rb) phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Letrozole selectively and reversibly inhibits aromatase, which may result in growth inhibition of estrogen-dependent cancer cells.","text":"An orally available co-packaged agent combination of the succinate salt form of ribociclib, a cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6, and letrozole, a nonsteroidal inhibitor of estrogen synthesis, with antineoplastic activity. Upon oral administration, ribociclib specifically inhibits CDK4 and CDK6, thereby inhibiting retinoblastoma (Rb) phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Letrozole selectively and reversibly inhibits aromatase, which may result in growth inhibition of estrogen-dependent cancer cells."},"drugInfoSummaryLink":{"uri":"https://www.cancer.gov/about-cancer/treatment/drugs/ribociclib-succinate-and-letrozole","text":"Ribociclib Succinate and Letrozole"},"nciConceptId":"C154675","nciConceptName":"Ribociclib/Letrozole","termId":816801,"name":"ribociclib succinate/letrozole","firstLetter":"r","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"ribociclib-letrozole"}],"links":null}