{"meta":{"totalResults":1,"from":0},"results":[{"aliases":[{"type":"USBrandName","name":"Sutent"},{"type":"Synonym","name":"sunitinib"},{"type":"LexicalVariant","name":"SU11248"},{"type":"CodeName","name":"SU11248"},{"type":"Abbreviation","name":"SU11248"},{"type":"ChemicalStructureName","name":"5-[5-fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide)"},{"type":"CodeName","name":"SU011248"},{"type":"CASRegistryName","name":"341031-54-7"},{"type":"ChemicalStructureName","name":"butanedioic acid, hydroxy-, (2S)-, compd. with N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (1:1)"}],"definition":{"html":"The orally bioavailable malate salt of an indolinone-based tyrosine kinase inhibitor with potential antineoplastic activity. Sunitinib blocks the tyrosine kinase activities of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor b (PDGFRb), and c-kit, thereby inhibiting angiogenesis and cell proliferation. This agent also inhibits the phosphorylation of Fms-related tyrosine kinase 3 (FLT3), another receptor tyrosine kinase expressed by some leukemic cells.","text":"The orally bioavailable malate salt of an indolinone-based tyrosine kinase inhibitor with potential antineoplastic activity. Sunitinib blocks the tyrosine kinase activities of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor b (PDGFRb), and c-kit, thereby inhibiting angiogenesis and cell proliferation. This agent also inhibits the phosphorylation of Fms-related tyrosine kinase 3 (FLT3), another receptor tyrosine kinase expressed by some leukemic cells."},"drugInfoSummaryLink":{"uri":"https://www.cancer.gov/about-cancer/treatment/drugs/sunitinibmalate","text":"Sunitinib Malate"},"nciConceptId":"C26673","nciConceptName":"Sunitinib Malate","termId":299061,"name":"sunitinib malate","firstLetter":"s","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"sunitinib-malate"}],"links":null}