{"meta":{"totalResults":1,"from":0},"results":[{"aliases":[{"type":"USBrandName","name":"Monjuvi"},{"type":"CodeName","name":"MOR-00208"},{"type":"CodeName","name":"MOR00208"},{"type":"CodeName","name":"MOR208"},{"type":"CodeName","name":"XmAb5574"},{"type":"Synonym","name":"tafasitamab"},{"type":"Synonym","name":"immunoglobulin, anti-(human Cd19 antigen) (human-mus musculus monoclonal MOR00208 heavy chain), disulfide with human-mus musculus monoclonal MOR00208 .kappa.-chain, dimer"},{"type":"CASRegistryName","name":"1422527-84-1"}],"definition":{"html":"An Fc engineered, humanized anti-CD19 monoclonal antibody directed against the B-cell-specific membrane protein CD19 with potential immunostimulating and antineoplastic activities. Tafasitamab-cxix targets and binds to CD19, thereby depleting and eliminating CD19-expressing B cells. The modified Fc region of XmAb5574 increases binding affinity to Fc-gamma receptors of effector cells and thereby enhances antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cell-mediated phagocytosis (ADCP). CD19 is widely expressed during B-cell development, from pro-B-cell to early plasma cell stages.","text":"An Fc engineered, humanized anti-CD19 monoclonal antibody directed against the B-cell-specific membrane protein CD19 with potential immunostimulating and antineoplastic activities. Tafasitamab-cxix targets and binds to CD19, thereby depleting and eliminating CD19-expressing B cells. The modified Fc region of XmAb5574 increases binding affinity to Fc-gamma receptors of effector cells and thereby enhances antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cell-mediated phagocytosis (ADCP). CD19 is widely expressed during B-cell development, from pro-B-cell to early plasma cell stages."},"drugInfoSummaryLink":{"uri":"https://www.cancer.gov/about-cancer/treatment/drugs/tafasitamab-cxix","text":"Tafasitamab-cxix"},"nciConceptId":"C95768","nciConceptName":"Tafasitamab","termId":682091,"name":"tafasitamab-cxix","firstLetter":"t","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"tafasitamab"}],"links":null}