{"meta":{"totalResults":1,"from":0},"results":[{"aliases":[{"type":"Synonym","name":"teclistamab"},{"type":"USBrandName","name":"Tecvayli"},{"type":"CodeName","name":"JNJ 64007957"},{"type":"CodeName","name":"JNJ-64007957"},{"type":"CodeName","name":"JNJ64007957"},{"type":"CASRegistryName","name":"2119595-80-9"}],"definition":{"html":"A bispecific humanized monoclonal antibody against human CD3, a T-cell surface antigen, and human B-cell maturation antigen (BCMA; TNFRSF17), a tumor-associated antigen (TAA) expressed on plasma cells, with potential antineoplastic activity. Upon administration, teclistamab-cqyv binds to both CD3 on T cells and BCMA expressed on malignant plasma cells. This results in the cross-linking of T cells and tumor cells, and induces a potent cytotoxic T-lymphocyte (CTL) response against BCMA-expressing plasma cells. BCMA, a member of the tumor necrosis factor receptor superfamily that is specifically overexpressed on malignant plasma cells, plays a key role in promoting plasma cell survival.","text":"A bispecific humanized monoclonal antibody against human CD3, a T-cell surface antigen, and human B-cell maturation antigen (BCMA; TNFRSF17), a tumor-associated antigen (TAA) expressed on plasma cells, with potential antineoplastic activity. Upon administration, teclistamab-cqyv binds to both CD3 on T cells and BCMA expressed on malignant plasma cells. This results in the cross-linking of T cells and tumor cells, and induces a potent cytotoxic T-lymphocyte (CTL) response against BCMA-expressing plasma cells. BCMA, a member of the tumor necrosis factor receptor superfamily that is specifically overexpressed on malignant plasma cells, plays a key role in promoting plasma cell survival."},"drugInfoSummaryLink":{"uri":"https://www.cancer.gov/about-cancer/treatment/drugs/teclistamab-cqyv","text":"Teclistamab-cqyv"},"nciConceptId":"C136823","nciConceptName":"Teclistamab","termId":789710,"name":"teclistamab-cqyv","firstLetter":"t","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"teclistamab"}],"links":null}