{"meta":{"totalResults":2,"from":0},"results":[{"aliases":[{"type":"Synonym","name":"busulfan/fludarabine/thiotepa regimen"},{"type":"Synonym","name":"busulfan/fludarabine/thiotepa"},{"type":"Synonym","name":"thiotepa/busulfan/fludarabine"},{"type":"Synonym","name":"fudarabine/busulfan/thiotepa regimen"},{"type":"Synonym","name":"thiotepa/busulfan/fludarabine regimen"}],"definition":{"html":"A regimen consisting of busulfan, fludarabine and thiotepa that is used as a conditioning regimen for hematopoietic stem cell transplantation (HSCT).","text":"A regimen consisting of busulfan, fludarabine and thiotepa that is used as a conditioning regimen for hematopoietic stem cell transplantation (HSCT)."},"drugInfoSummaryLink":null,"nciConceptId":"C185955","nciConceptName":"TBF Regimen","termId":809606,"name":"TBF regimen","firstLetter":"t","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"tbf-regimen"},{"aliases":[{"type":"Synonym","name":"triethylene thiophosphoramide"},{"type":"Synonym","name":"triethylenethiophosphoramide"},{"type":"USBrandName","name":"Tepadina"},{"type":"Abbreviation","name":"TSPA"},{"type":"Synonym","name":"thiophosphamide"},{"type":"Synonym","name":"thiophosphoamide"},{"type":"ChemicalStructureName","name":"1,1',1\"-phosphinothioylidynetrisaziridine"},{"type":"Synonym","name":"thiofosfamide"},{"type":"CodeName","name":"WR 45312"},{"type":"Synonym","name":"thiophosphoramide"},{"type":"ChemicalStructureName","name":"N,N',N''-triethylenethiophosphoramide"},{"type":"Abbreviation","name":"TESPA"},{"type":"ChemicalStructureName","name":"1,1',1''-phosphinothioyldynetrisaziridine"},{"type":"ChemicalStructureName","name":"tris(1-aziridinyl)phosphine sulfide"},{"type":"ObsoleteName","name":"Thioplex"},{"type":"CodeName","name":"SH-105"},{"type":"CodeName","name":"SH 105"},{"type":"CodeName","name":"SH105"},{"type":"USBrandName","name":"Tepylute"},{"type":"CASRegistryName","name":"52-24-4"}],"definition":{"html":"A polyfunctional, organophosphorus alkylating agent and a stable derivative of N,N',N''-triethylenephosphoramide (TEPA), with antineoplastic activity. Upon administration, thiotepa is converted into highly reactive ethylenimine groups, which covalently bind to nucleophilic groups in DNA and demonstrate a preference for the N7 position of guanine bases. This induces crosslinking of alkylated guanine bases in double-stranded DNA, interferes with both DNA replication and cell division, and results in both the induction of apoptosis and the inhibition of cell growth.","text":"A polyfunctional, organophosphorus alkylating agent and a stable derivative of N,N',N''-triethylenephosphoramide (TEPA), with antineoplastic activity. Upon administration, thiotepa is converted into highly reactive ethylenimine groups, which covalently bind to nucleophilic groups in DNA and demonstrate a preference for the N7 position of guanine bases. This induces crosslinking of alkylated guanine bases in double-stranded DNA, interferes with both DNA replication and cell division, and results in both the induction of apoptosis and the inhibition of cell growth."},"drugInfoSummaryLink":{"uri":"https://www.cancer.gov/about-cancer/treatment/drugs/thiotepa","text":"Thiotepa"},"nciConceptId":"C875","nciConceptName":"Thiotepa","termId":42933,"name":"thiotepa","firstLetter":"t","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"thiotepa"}],"links":null}