{"meta":{"totalResults":1,"from":0},"results":[{"aliases":[{"type":"LexicalVariant","name":"ecteinascidin 743"},{"type":"LexicalVariant","name":"ecteinascidin-743"},{"type":"USBrandName","name":"Yondelis"},{"type":"ForeignBrandName","name":"Yondelis"},{"type":"Abbreviation","name":"ET 743"},{"type":"Synonym","name":"ecteinascidin"},{"type":"NSCNumber","name":"648766"},{"type":"CASRegistryName","name":"114899-77-3"}],"definition":{"html":"A tetrahydroisoquinoline alkaloid isolated from the marine tunicate Ecteinascidia turbinate with potential antineoplastic activity.  Binding to the minor groove of DNA, trabectedin inteferes with the transcription-coupled nucleotide excision repair machinery to induce lethal DNA strand breaks.and blocks the cell cycle in the G2 phase.  ","text":"A tetrahydroisoquinoline alkaloid isolated from the marine tunicate Ecteinascidia turbinate with potential antineoplastic activity.  Binding to the minor groove of DNA, trabectedin inteferes with the transcription-coupled nucleotide excision repair machinery to induce lethal DNA strand breaks.and blocks the cell cycle in the G2 phase.  "},"drugInfoSummaryLink":{"uri":"https://www.cancer.gov/about-cancer/treatment/drugs/trabectedin","text":"Trabectedin"},"nciConceptId":"C1691","nciConceptName":"Trabectedin","termId":42577,"name":"trabectedin","firstLetter":"t","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"trabectedin"}],"links":null}