{"meta":{"totalResults":1,"from":0},"results":[{"aliases":[{"type":"CodeName","name":"REGN4018"},{"type":"CodeName","name":"REGN 4018"},{"type":"CodeName","name":"REGN-4018"},{"type":"Synonym","name":"MUC16xCD3 bispecific T-cell engager REGN4018"},{"type":"Synonym","name":"bispecific T-cell engager antibody REGN4018"},{"type":"Synonym","name":"MUC16/CD3-directed bispecific T-cell engager antibody REGN4018"},{"type":"CASRegistryName","name":"2305629-50-7"},{"type":"Synonym","name":"anti-MUC16 x anti-CD3 REGN4018"},{"type":"Synonym","name":"anti-MUC16/CD3 bispecific antibody REGN4018"}],"definition":{"html":"A bispecific, human monoclonal antibody with potential antineoplastic activity. REGN4018 contains two antigen-recognition sites: one for human CD3, a T-cell surface antigen that is part of the T-cell receptor complex, and one for human mucin 16 (MUC16, cancer antigen 125; CA125; FLJ14303), a member of the mucin family of glycoproteins that is overexpressed by several epithelial cancers, including ovarian cancer. Upon administration, ubamatamab binds to both T cells and MUC16-expressing tumor cells, which cross-links the T cells to the tumor cells, and may result in a potent cytotoxic T-lymphocyte (CTL) response against the MUC16-expressing tumor cells.","text":"A bispecific, human monoclonal antibody with potential antineoplastic activity. REGN4018 contains two antigen-recognition sites: one for human CD3, a T-cell surface antigen that is part of the T-cell receptor complex, and one for human mucin 16 (MUC16, cancer antigen 125; CA125; FLJ14303), a member of the mucin family of glycoproteins that is overexpressed by several epithelial cancers, including ovarian cancer. Upon administration, ubamatamab binds to both T cells and MUC16-expressing tumor cells, which cross-links the T cells to the tumor cells, and may result in a potent cytotoxic T-lymphocyte (CTL) response against the MUC16-expressing tumor cells."},"drugInfoSummaryLink":null,"nciConceptId":"C153129","nciConceptName":"Ubamatamab","termId":793937,"name":"ubamatamab","firstLetter":"u","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"ubamatamab"}],"links":null}