{"aliases":[{"type":"USBrandName","name":"Spiriva"},{"type":"ChemicalStructureName","name":"1,4-Dihydro-3,5-Diiodo-1-Methyl-4-Oxopyridine-2,6-Dicarboxylic Acid"},{"type":"ChemicalStructureName","name":"6.Beta.,7.Beta.-Epoxy-3.Beta.-Hydroxy-8-Methyl-1.Alpha.H,5.Alpha.H-Tropanium Bromide, Di-2-Thienylglycolate Monohydrate"}],"definition":{"html":"The monohydrate bromide salt form of tiotropium, a quaternary ammonium derivative of atropine and a long-acting muscarinic receptor antagonist, with bronchodilating activity. Upon inhalation, tiotropium binds to and blocks mainly muscarinic M3 receptors located on smooth muscle cells, thereby preventing smooth muscle contraction","text":"The monohydrate bromide salt form of tiotropium, a quaternary ammonium derivative of atropine and a long-acting muscarinic receptor antagonist, with bronchodilating activity. Upon inhalation, tiotropium binds to and blocks mainly muscarinic M3 receptors located on smooth muscle cells, thereby preventing smooth muscle contraction"},"drugInfoSummaryLink":null,"nciConceptId":"C61974","nciConceptName":"Tiotropium Bromide Monohydrate","termId":682857,"name":"tiotropium bromide monohydrate","firstLetter":"t","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"tiotropium-bromide-monohydrate"}