{"aliases":[{"type":"USBrandName","name":"Venclexta"},{"type":"CodeName","name":"ABT-199"},{"type":"Synonym","name":"RG7601"},{"type":"CodeName","name":"GDC-0199"},{"type":"CodeName","name":"ABT199"},{"type":"CodeName","name":"ABT-0199"},{"type":"Synonym","name":"Bcl-2 inhibitor GDC-0199"},{"type":"CASRegistryName","name":"1257044-40-8"},{"type":"ChemicalStructureName","name":"4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-((tetrahydro-2H-pyran-4-ylmethyl)amino)phenyl)sulfonyl)-2-(1H-pyrrolo(2,3-b)pyridin-5-yloxy)benzamide"},{"type":"ForeignBrandName","name":"Venclyxto"}],"definition":{"html":"An orally bioavailable, selective small molecule inhibitor of the anti-apoptotic protein Bcl-2, with potential antineoplastic activity. Venetoclax mimics BH3-only proteins, the native ligands of Bcl-2 and apoptosis activators, by binding to the hydrophobic groove of Bcl-2 proteins thereby repressing Bcl-2 activity and restoring apoptotic processes in tumor cells. Bcl-2 protein is overexpressed in some cancers and plays an important role in the regulation of apoptosis; its expression is associated with increased drug resistance and tumor cell survival. Compared to the Bcl-2 inhibitor navitoclax, this agent does not inhibit bcl-XL and does not cause bcl-XL-mediated thrombocytopenia.","text":"An orally bioavailable, selective small molecule inhibitor of the anti-apoptotic protein Bcl-2, with potential antineoplastic activity. Venetoclax mimics BH3-only proteins, the native ligands of Bcl-2 and apoptosis activators, by binding to the hydrophobic groove of Bcl-2 proteins thereby repressing Bcl-2 activity and restoring apoptotic processes in tumor cells. Bcl-2 protein is overexpressed in some cancers and plays an important role in the regulation of apoptosis; its expression is associated with increased drug resistance and tumor cell survival. Compared to the Bcl-2 inhibitor navitoclax, this agent does not inhibit bcl-XL and does not cause bcl-XL-mediated thrombocytopenia."},"drugInfoSummaryLink":{"uri":"https://www.cancer.gov/about-cancer/treatment/drugs/venetoclax","text":"Venetoclax"},"nciConceptId":"C103147","nciConceptName":"Venetoclax","termId":698675,"name":"venetoclax","firstLetter":"v","type":"DrugTerm","termNameType":"PreferredName","prettyUrlName":"venetoclax"}